Putting pharmacokinetics into practice, this timely and comprehensive text delivers the latest procedures and data on today's drugs and patient-specific dosing.
* The best guide to pharmacokinetics for real-life pharmacy practice
*Ideal for students, pharmacists, and other clinicians who want clear, useful, and up-to-date coverage of the latest standardized techniques and most recent pharmacokinetically monitored drugs
*Essential topics for pharmaceutics, pharmacokinetics, therapeutics, and clinical pharmacy courses or can be used in a self-directed manner to self-teach or review important concepts and techniques
*Inside: essential information on approaches to drug-dosing and monitoring in individual patients, including the latest data on serum concentrations, written by a nationally recognized leader in pharmacokinetics
The most up-to-date and practical text in the field, Applied Clinical Pharmacokinetics features
*Clear, useful coverage of drug dosing and drug monitoring today
*Focus on the latest standardized techniques and approaches to patient-specific dosing
*Up-to-date information on more recently monitored drugs
*Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure
*All the information practitioners need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants
*Full coverage of drugs such as Aminoglycosides, Vancomycin, Digoxin, Phenytoin, Carbamazepine, Theophylline, Cyclosporine, Tacrolimus, and Lithium
*Clear and concise summary of pharmacokinetic and pharmacodynamic concepts
*Practical help with calculations and equations
*50 useful charts and illustrations
*18 chapters that provide needed hands-on guidance in techniques, procedures, and approaches
*Tools that make learning and use easier, including a principle-clarifying introductory chapter, examples of calculations, and questions and answers to test your understanding
Reviewer:Kelly Ann Sprandel, PharmD(University of Illinois at Chicago College of Pharmacy)
Description:This book provides information on clinical pharmacokinetics and therapeutic drug monitoring.
Purpose:The purpose is to provide basic pharmacokinetic/pharmacodynamic concepts as well as information on how to initiate and monitor drug therapy using pharmacokinetic calculations. The book is designed to teach computation of drug doses and modification based on serum concentrations. These pharmacokinetic calculations are relevant to clinical practice where therapeutic drug monitoring is performed. The author has provided sufficient information about specific medications to achieve the objectives..
Audience:According to the author, the book is targeted toward clinical practitioners regardless of their professional background (i.e., pharmacists, physicians, nurse practitioners, physician assistants) and toward pharmacy students. In my judgment, this book may be most appropriate for pharmacists and for those teaching pharmacy students. The author's area of specialty is clinical pharmacokinetics and he is a credible authority on the subject.
Features:In each chapter, the author focuses on a specific drug and provides a short discussion on its basic pharmacology and mechanism of action. Next, he presents clinical pharmacokinetic monitoring parameters, effects of disease states/conditions on the pharmacokinetics of the drug, potential drug interactions, and methods (with examples) on how to compute initial doses and modify drug therapy based on serum drug concentrations. Each chapter concludes with example problems andsolutions. The book offers complete, easy to follow, step-by-step explanations and covers a wide range of therapeutic agents (antibiotics, anticonvulsants, immunosuppressants, etc). It does not, however, include a chapter on anticoagulants. This is an excellent teaching tool, but the length of the chapters may detract from its use as a quick reference.
Assessment:This is an excellent resource of pharmacokinetic information for students and clinicians. This pharmacokinetic information can also be obtained from other books such as Evans' et al.'s Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring, 3rd edition (Lippincott Williams & Wilkins, 1992). However, the material in this book is presented in a more student-friendly manner with extensive explanations and example problems.