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Principles of Clinical Pharmacology, Second Edition

Principles of Clinical Pharmacology, Second Edition
Author: N/A
ISBN 13: 9780123694171
ISBN 10: 123694175
Edition: 2
Publisher: Academic Press
Publication Date: 2006-10-04
Format: Hardcover
Pages: 568
List Price: $131.00

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

New to the Second Edition

The Second Edition retains the goal, format, and presentation style of the first edition but has been extensively updated and revised with the inclusion of many new authors and co-authors. In addition the second edition features:

* Pharmacogenetics - Expanded coverage of pharmacogenetics.

* Expanded coverage of drug transporters and their role in interactions.

* New material added on enzyme induction mechanisms to the chapters on drug metabolism and drug interactions.

* New Chapter!-A new chapter on Drug Discovery has been added with a focus on oncologic agents.

* New coverage of therapeutic antibodies has been added to the chapter on biotechnology products.

Hallmark Features

* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy.

* Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course.

* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study.

* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.

Doody Review Services

Reviewer:Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description:This is an updated and expanded version of the original book published five years ago as an outgrowth of a course taught for several years at the NIH Clinical Center. Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book.
Purpose:The purpose of this offering is to serve as a text for an advanced principles of clinical pharmacology course such as the one offered at the NIH Clinical Center. It serves this role well.
Audience:The book assumes that the reader is adequately versed in calculus, basic pharmacology, physiology, and clinical medicine. It is best suited for graduate students and fellows seeking advanced training in the principles of clinical pharmacology.
Features:An introductory chapter on the discipline of clinical pharmacology opens the book, followed by nine chapters on the basic principles of pharmacokinetics. The next part deals with drug metabolism and membrane transport with a special emphasis on the advances that have been made in the understanding of transport mechanisms. Part III deals with the assessment of drug effects primarily in experimental animals, whereas Part IV deals with optimizing and evaluating patient therapy with special emphasis on the impact that gender, pregnancy, age, and disease have on the clinical use of drugs in these populations. The last part deals with recent advances in drug discovery and development. Several chapters have excellent study problems and questions at the end with explanations provided in the appendix. The book is appropriately referenced.
Assessment:This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome.