Written for advanced undergraduate and graduate students as well as professionals in organic and medicinal chemistry and biochemistry, this unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Enzyme-catalyzed reactions are essential for the design of enzyme inhibitors in the pharmaceutical and agricultural industries, and of growing importance for process development in the chemical and biotechnology industries. Following a general introduction to the role of enzymes as catalysts, each chapter describes the organic reaction mechanisms that are used by enzymes to catalyze a particular family of organic transformations. The compilation includes a vast number of drawings to illustrate structures and mechanisms, and focuses on one or two examples of enzymes that catalyze the particular chemistry for that transformation. The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather the general mechanisms used by enzymes. Extensive references refer to the many experiments that have helped to elucidate enzyme mechanisms. Chemical model studies as an aid in mechanistic studies are also discussed, as are the design of haptens and the generation of catalytic antibodies ("designer enzymes"). Problem sets and solutions are provided to check the reader's understanding of the principles described.
An enzymology text for organic chemists and an organic chemistry text for enzymologists designed primarily for a one-semester course, but also usable as the core of a one-year course with additional material. It shows organic chemists that enzymology is simply a biological application of physical organic chemistry, and shows biochemists how to view it from the perspective of organic chemical mechanisms. The first edition appeared in 2000. Annotation c. Book News, Inc., Portland, OR