For the new edition of this text on medicinal chemistry and molecular pharmacology, the authors have extensively updated the material to take into account advances since the publication of the second edition in 1998. They have added descriptions of new techniques of modeling, applications of genomics in drug design, therapies for Alzheimer's and other diseases, and emerging disorders like those of protein folding. Otherwise, the overall structure has remained unchanged with chapters first presenting the basic principles of medicinal chemistry and then looking at applications from a target- centered viewpoint. Annotation ©2005 Book News, Inc., Portland, OR
Reviewer:Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description:This medicinal chemistry textbook provides introductory information on basic molecular principles of drug design followed by applications of medicinal chemistry from a target-centered viewpoint. This third edition not only updates new information but focuses on the prominent role of molecular modeling, high throughput screening, and genomics on drug design and discovery.
Purpose:The purpose is to provide the core biochemical and molecular principles needed in an introductory medicinal chemistry course and then apply these principles towards understanding the mechanisms by which drugs affect specific targets and diseases. This is a very readable book that can be understood by a basic chemist or a clinical practitioner. The authors have done a remarkable job of preparing a textbook that is comprehensive, authoritative, and readable.
Audience:This book is valuable for students and scientists in chemistry, pharmacy, and medicine. Since Donald Weaver is both a medicinal chemist and clinical neurologist and Thomas Norgrady is a retired professor, this book has perspectives and insights that are unique and often missing from many medicinal chemistry textbooks.
Features:The first part is devoted to basic principles with a chapter on structure and properties of drug molecules, a chapter on structure and properties of receptors, and a chapter on designing drug molecules to fit receptors. Part two deals with specific drug targets including: neurotransmitters; hormones; immunomodulators; endogenous cellular structures such as ion channels, lipid membranes, transporters, cytoplasmic organelles and the nucleus; endogenous macromolecules such as proteins, lipids, carbohydrates and nucleic acids; and exogenous pathogens and toxins such as prions, viruses, bacteria, fungi, and parasites. Most chapters have a newly added feature entitled Clinical-Molecular Interface that highlights specific diseases such as collagen diseases or pneumonia. This edition also highlights the numerous advances that have been accomplished in developing drugs that treat nervous system and immunological diseases. The appendix provides a list of drugs arranged by pharmacological activity.
Assessment:The third edition of this popular textbook remains unique, authoritative, comprehensive and readable. Through a systematic organization of drug targets, all the important human disease and major categories of drugs are discussed providing insights into drug mechanisms and approaches to drug discovery. I highly recommend this book.