Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Reviewer:Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description:This book, a third edition, provides comprehensive coverage of cytochrome P450. A particular asset is the extensive bibliography provided for each chapter. Previous editions were published 10 and 20 years ago.
Purpose:The goal is to provide updated information on all aspects of cytochrome P450. Given the importance of this family of proteins in many areas of metabolism, this is highly worthwhile. The book succeeds well.
Audience:Material in this book will serve a broad audience: advanced students, fellows, and senior investigators. Those not working in the area will also find material of interest, particularly on mechanism of action and breadth.
Features:In the 10 years since the previous edition of this book was published, much new material has been developed, mechanisms better understood, and the diversity of the P450 family better defined. Hence the impetus for a new look. Material covered in this edition includes a section on mechanism, cosubstrates (the reducing partners), oxygen management, plant and bacterial sources, and a comprehensive article on human variants. The latter is particularly distinguished by exhaustive coverage and an impressive bibliography; this feature alone makes this edition a worthwhile investment. The editor has assembled an excellent group of contributors and maintained high standards throughout. The importance of this family of proteins in the metabolism of externally acquired materials (mainly organics and including most drugs) is well developed. The genetic aspects are also discussed with specific inductions a focus. Research laboratories in both academic and drug company settings will find much useful material here.
Assessment:An impressive achievement. The 1,500 references in the chapter on human P450 (a small book in itself) are a major asset. Even individuals far removed (scientifically) will find material of interest. Certainly all students and fellows working in this area will want a copy.