The Pulitzer Prize winning "Arrowsmith" (an award Lewis refused to accept) recounts the story of a doctor who is forced to give up his trade for reasons ranging from public ignorance to the publicity-mindedness of a great foundation, and becomes an isolated seeker of scientific truth. Introduction by E.L. Doctorow.
One closes the novel with a feeling that, if eternal verities be the ultimate objective, no great progress has been made. Mr. Lewis has attacked spiritedly, but he has not advanced. -- Books of the Century; New York Times review, March 1925